SPHEROIDS, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS

摘要

The invention relates to a directly-compressible gastro-resistant spheroid. The inventive spheroid is characterised in that it comprises: (i) a core containing one or more active substances; (ii) a flexible, deformable film which is used directly to coat the aforementioned core and which comprises an enteric polymer and a mixture of saturated and/or unsaturated polyglycosylated glycerides, the fatty acids of which include at least 8 carbon atoms; and an outer water-dispersible layer containing at least one disintegrating agent.