发明名称 |
DIAGNOSTIC OR THERAPEUTIC SOMATOSTATIN OR BOMBESIN ANALOG CONJUGATES AND USES THEREOF |
摘要 |
Disclosed are peptide agents and uses thereof that are analogs of biologically active peptides such as somatostatin and bombesin. The compounds of the invention have the general formula X-Y-Z-Q, where X is a cytotoxic agent, therapeutic agent, detectable label or chelating group, and Q is a biologically active peptide. In peptide agents of the invention Y is optionally a hydrophilic polymer or peptide, and Z is a linking peptide bonded to Q at the amino terminus of Q, having two, three, four, or five, amino acid residues selected to link X to Q, while retaining the biological activity of Q. Methods of using these peptide agents in the diagnosis and treatment of diseases are also disclosed.
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申请公布号 |
WO03028527(A8) |
申请公布日期 |
2004.04.15 |
申请号 |
WO2002US30143 |
申请日期 |
2002.09.20 |
申请人 |
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND;COY, DAVID, H.;FUSELIER, JOSEPH, A.;MURPHY, WILLIAM, A.;SUN, LICHUN |
发明人 |
COY, DAVID, H.;FUSELIER, JOSEPH, A.;MURPHY, WILLIAM, A.;SUN, LICHUN |
分类号 |
A61K47/48;A61B;A61B1/00;A61K;A61K31/165;A61K31/4745;A61K31/519;A61K38/00;A61K38/08;A61K38/10;A61K38/31;A61K47/42;A61K49/00;A61K51/00;A61K51/08;A61P1/00;A61P9/00;A61P11/00;A61P13/08;A61P15/00;A61P25/00;A61P27/02;A61P35/00;C07K7/06;C07K7/08;C07K14/655;(IPC1-7):A61K38/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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