发明名称 |
Tolerogenic antigen-presenting cells |
摘要 |
It has been found that dendritic cells can be prepared which cannot mature. These cells can provide signal 1 to T cells but cannot provide co-stimulatory signal 2. T cells which are stimulated by the permanently immature dendritic cells therefore anergise, so the dendritic cells are tolerogenic rather than immunogenic. The cells are generally CD40<-ve>, CD80<-ve >and CD86<-ve>, and remain so when stimulated by inflammatory mediators such as lipopolysaccharide. The cells can be prepared conveniently by the culturing adherent embryonic stem cells in the presence of GM-CSF.
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申请公布号 |
US2004072348(A1) |
申请公布日期 |
2004.04.15 |
申请号 |
US20030402442 |
申请日期 |
2003.03.28 |
申请人 |
LEISHMAN ANDREW JAMES;INNES DONALD ALAN JAMES;MOORE MARILYN JEAN |
发明人 |
LEISHMAN ANDREW JAMES;INNES DONALD ALAN JAMES;MOORE MARILYN JEAN |
分类号 |
A61K35/12;A61K35/28;A61K35/48;A61K48/00;A61L27/00;A61P37/06;C12N5/0784;C12N5/10;(IPC1-7):C12N5/08;A61K45/00 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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