发明名称 |
Isolation of a rearranged human immunoglobulin gene from a chimeric mouse and recombinant production of the encoded immunoglobulin |
摘要 |
The specification relates to a method for producing a chimeric non-human animal, which comprises preparing a microcell containing a foreign chromosome(s) or a fragment(s) thereof and transferring the foreign chromosome(s) or fragment(s) thereof into a pluripotent cell by fusion with the microcell; a chimeric non-human animal which can be produced by the above method and its progeny; tissues and cells derived therefrom; and a method for using the same. Further, a pluripotent cell containing a foreign chromosome(s) or a fragment(s) thereof, a method for producing the same, and a method for using the same are also provided. Moreover, a pluripotent cell in which at least two endogenous genes are disrupted, and a method for producing the same by homologous recombination are provided.
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申请公布号 |
US2004073957(A1) |
申请公布日期 |
2004.04.15 |
申请号 |
US20030418251 |
申请日期 |
2003.11.13 |
申请人 |
KIRIN BEER KABUSHIKI KAISHA |
发明人 |
TOMIZUKA KAZUMA;YOSHIDA HITOSHI;HANAOKA KAZUNORI;OSHIMURA MITSUO;ISHIDA ISAO |
分类号 |
A01K67/027;C07K16/00;C07K16/18;C12N15/85;C12N15/90;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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