DIFFERENTIALLY EXPRESSED GENES INVOLVED IN ANGIOGENESIS, THE PROTEINS ENCODED THEREBY, AND METHODS OF USING THE SAME
摘要
The invention relates generally to the identification of nucleic acids and their encoded polypeptides, particularly VCC1, whose expression is modulated in angiogenesis. These nucleic acids and proteins have not previously been identified as having a biological role in angiogenesis. The invention further relates to compounds that modulate VCC1 expression and/or activity. Methods of using these compounds for modulation of VCC-1 expression and for treatment of diseases associated with expression of VCC-1 are provided. Also included are methods of diagnosis of VCC1 associated angiogenic disorders.
申请公布号
WO03087157(A3)
申请公布日期
2004.04.15
申请号
WO2003US11088
申请日期
2003.04.11
申请人
PHARMACIA CORPORATION;WEINSTEIN, EDWARD, J.;HEAD, RICHARD, D.;MAZZARELLA, RICHARD;GRIGGS, DAVID, W.
发明人
WEINSTEIN, EDWARD, J.;HEAD, RICHARD, D.;MAZZARELLA, RICHARD;GRIGGS, DAVID, W.