ARTIFICIAL CHROMOSOMES COMPRISING CONCATEMERS OF EXPRESSIBLE NUCLEOTIDE SEQUENCES

摘要

In the present invention is disclosed the use of artificial chromosomes for the coordinated and controllable expression of large numbers of heterologous genes in a single host cell. In particular, the invention relates to an artificial chromosome comprising at least two co-ordinatedly expressible nucleotide sequences, an artificial chromosome comprising at least two expression cassettes and a host cell comprising at least one of these artificial chromosomes as well as to a host cell comprising at least three different artificial chromosomes.