发明名称 |
SPHERICAL PELLET CONTAINING A WATER-SOLUBLE ACTIVE INGREDIENT |
摘要 |
A process for preparing spherical pellets comprising (a) a water-soluble active ingredient soluble, freely soluble or very soluble in water; and in particular having a water-solubility of >= 0.5 g/ml; (b) a spheronizing agent; (c) a dry lubricant, said method comprising preparing a mixture of the active ingredient, the spheronising agent, the dry lubricant; and an amount of water which is less than 5%, w/w relative to the total weight of the mixture; extruding said mixture to obtain an extrudate; and spheronising the extrudate to form spherical pellets. The invention further concerns pellets obtained by this process and sustained release oral dosage forms containing said pellets. |
申请公布号 |
WO2004002398(A3) |
申请公布日期 |
2004.04.15 |
申请号 |
WO2003EP06831 |
申请日期 |
2003.06.25 |
申请人 |
CILAG AG;STRONG, BRIAN;KLOEMKES, MARTIN;BACHMANN, DIETER |
发明人 |
STRONG, BRIAN;KLOEMKES, MARTIN;BACHMANN, DIETER |
分类号 |
A61K6/00;A61K9/16;A61K9/54;A61K31/135;A61K47/14;A61K47/38;A61P29/02 |
主分类号 |
A61K6/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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