发明名称 |
NOVEL ALIPHATIC COMPOUND, METHOD OF SYNTHESIS, AND METHOD OF UTILIZATION |
摘要 |
<p>Fatty acid amide derivatives (I) are new. Fatty acid amide derivatives of formula (I) and their stereoisomers and salts are new. [Image] A : C nH (2n-2m)-CH 3; n : 4-22; m : number of unsaturated bonds and is 0-7; l : 0-10; s : 0; p+q : 4-5; or s : 1; and p+q : 3-4; R : 1-10C alkyl; and R AH or 1-10C alkyl. ACTIVITY : Antiaggregant; Antiinflammatory; Cardiant; Antiarteriosclerotic; Cerebroprotective; Vasotropic; Thrombolytic; Antianginal; Hepatotropic; Antilipemic. MECHANISM OF ACTION : Cytokine-Antagonist; TNF-Antagonist-alpha ; PDGF-Antagonist; Cholesterol-Antagonist. In assays, (4Z,7Z,10Z,13Z,16Z,19Z)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]docosahexaenamide (Ia) inhibited platelet aggregation with an IC 5 0 of 1.5 MicroM, compared to 5.0 MicroM for indomethacin.</p> |
申请公布号 |
EP1408030(A1) |
申请公布日期 |
2004.04.14 |
申请号 |
EP20020738748 |
申请日期 |
2002.06.18 |
申请人 |
MARUHA CORPORATION |
发明人 |
TAMAI, T.;YOSHIKAI, K.;NISHIKAWA, M.;OGASAWARA, KUNIO;MUROTA, I. |
分类号 |
A61K31/40;A61K31/495;A61P9/00;A61P9/10;A61P29/00;C07D207/09;C07D295/32;(IPC1-7):C07D207/09;C07D295/22 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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