发明名称 |
Microorganisms exhibiting increased production and increased biological availability of a folate |
摘要 |
The invention provides a process of producing bio-available folate, i.e. folic acid having an increased proportion of monoglutamyl folate and a decreased proportion of polyglutamyl folate, by culturing micro-organisms containing an active heterologous or homologous polyglutamyl hydrolase activity or containing increased activities of folate biosynthesis enzymes. The genes encoding the polyglutamyl hydrolase and the folate biosynthesis enzymes may be of various origin, e.g. from rodents or other mammals including man. Also provided is a foodstuff, especially a dairy product containing such monoglutamyl folate-producing micro-organisms. |
申请公布号 |
CZ20033565(A3) |
申请公布日期 |
2004.04.14 |
申请号 |
CZ20030003565 |
申请日期 |
2002.05.28 |
申请人 |
CAMPINA B. V. |
发明人 |
SYBESMA WILBERT FEIKE HENRICUS;HUGENHOLTZ JEROEN;MIERAU IGOR;STARRENBURG MARIA JOHANNA CATHARINA;KLEEREBEZEM MICHIEL;DE VOS WILLEM MEINDERT |
分类号 |
A23C9/123;A23C19/032;A23C21/02;A23L1/03;A23L1/30;A23L1/302;A23L1/305;A61K31/525;A61K35/66;A61K35/74;A61P3/02;A61P7/06;C12N1/00;C12N1/20;C12N1/21;C12N9/48;C12N15/09;C12N15/52;C12P7/44;C12P13/02;C12P17/12;C12P17/18;C12R1/01 |
主分类号 |
A23C9/123 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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