PROCESS FOR THE PREPARATION OF 7-AMINO SYN 3,5-DIHYDROXY HEPTANOIC ACID DERIVATIVES VIA 6-CYANO SYN 3,5-DIHYDROXY HEXANOIC ACID DERIVATIVES

摘要

The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein R_a and R_c are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and R_b is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein R_a and R_c are each independently of the other hydrogen or a hydroxy-protecting group, and R_b is a carboxy-protective group