发明名称 |
Compositions and methods for regulating bacterial pathogenesis |
摘要 |
This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides is a new class of bacterial genes involved in the biosynthesis of the signaling molecule.
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申请公布号 |
US6720415(B2) |
申请公布日期 |
2004.04.13 |
申请号 |
US19990453976 |
申请日期 |
1999.12.02 |
申请人 |
PRINCETON UNIVERSITY;UNIVERSITY TECHNOLOGIES INTERNATIONAL |
发明人 |
BASSLER BONNIE L.;SURETTE MICHAEL G. |
分类号 |
A61K31/00;A61K38/00;C07K14/195;C12N1/21;C12Q1/18;C12Q1/68;(IPC1-7):C07H21/04 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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