DERIVATIVES OF ORTHO-ANTRANILAMIDE AS ANTI-COAGULATING AGENTS, PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT

摘要

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to ortho-antranilamide derivatives of the formula (I): wherein A means =CH- or =N; m means a whole number 1-3; n means a whole number 1-4; D means -N(R5)-C(Z)- or -N(R5)-S(O)p- (wherein p means 0-2; Z means oxygen or sulfur atom or H2, and nitrogen atom is bound with phenyl ring comprising substituents R1 and R2); E means C(Z)-N(R5)- or -S(O)p-N(R5)- (wherein p means 0-2; Z means oxygen or sulfur atom or H2 and nitrogen atom can be bound with phenyl ring comprising substituents R1 and R2 or with aromatic ring comprising a substituent R4). Compounds inhibit the enzyme, factor Xa, owing to they can be used as anti-coagulating agents. Invention describes pharmaceutical composition and method for treatment using compounds of the formula (I) also. EFFECT: valuable medicinal properties of compounds. 66 cl, 54 ex