COMPOSITIONS AND METHODS FOR TREATMENT OF OSTEOARTHRITIS

摘要

The present invention is based upon methods of treating musculoskeletal or proinflammatory conditions and pathologies in mammals using. Methods of using the polynucleotide sequences and the the polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using OAX polynucleotide sequences and the OAX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. OAX collectively refers to any of six variant OAX sequences, variously designated OAl, OA2, OA3, and OA4.