NONINVASIVE LOCALIZATION OF LUMINESCENT COMPLEX IN MAMMAL

摘要

PROBLEM TO BE SOLVED: To provide a noninvasive method for detecting, positioning and tracing a pathogen in the living body such as a mammal and the like. SOLUTION: The noninvasive method includes a process for providing a nonhuman mammal control having cells containing an introduced gene in detecting expression of a heterogene in the nonhuman mammal control. In the process (i) the introduced gene contains the heterogene coding for a bioluminescent protein or a fluorogenic protein and (ii) the control contains an opaque tissue, the expression of the heterogene is detected by measuring photon radiation passing through the opaque tissue by using a photodetector and the control is maintained under a condition permissible for expressing the heterogene by the cells. COPYRIGHT: (C)2004,JPO