发明名称 |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
摘要 |
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
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申请公布号 |
US2004067945(A1) |
申请公布日期 |
2004.04.08 |
申请号 |
US20030365740 |
申请日期 |
2003.02.12 |
申请人 |
NIEWOHNER ULRICH;NIEWOHNER MARIA;ES-SAYED MAZEN;HANING HELMUT;SCHENKE THOMAS;SCHLEMMER KARL-HEINZ;KELDENICH JORG;BISCHOFF ERWIN;PERZBORN ELISABETH;DEMBOWSKY KLAUS;SERNO PETER;NOWAKOWSKI MARC |
发明人 |
NIEWOHNER ULRICH;NIEWOHNER MARIA;ES-SAYED MAZEN;HANING HELMUT;SCHENKE THOMAS;SCHLEMMER KARL-HEINZ;KELDENICH JORG;BISCHOFF ERWIN;PERZBORN ELISABETH;DEMBOWSKY KLAUS;SERNO PETER;NOWAKOWSKI MARC |
分类号 |
A61K31/53;A61K31/5375;A61K31/5377;A61K31/541;A61K31/55;A61K31/551;A61K31/662;A61P9/00;A61P9/10;A61P11/08;A61P13/02;A61P13/08;A61P13/10;A61P15/00;A61P15/10;A61P43/00;C07D;C07D487/04;C07D491/113;C07D519/00;C07F9/6561;(IPC1-7):A61K31/53;A61K31/675 |
主分类号 |
A61K31/53 |
代理机构 |
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