MODIFIED RELEASE DOSAGE FORMS

摘要

A dosage form comprises: (a) at least one active ingredient; (b) a core havi ng an outer surface; and (c) a shell which resides upon at least a portion of t he core outer surface, wherein at least a portion of the shell is semipermeable , such that the liquid medium diffuses through the semipermeable shell or shel l portion to the core due to osmosis. The shell also provides for delivery of the active ingredient to a liquid medium outside the shell after contacting of the dosage form with the liquid medium. The dosage form delivers one or more active ingredients in a controlled manner upon contacting of the dosage form with a liquid medium. The dosage form may be employed to provide a burst release of the active ingredient, or to provide release of the active ingredient at an ascending release rate over an extended time period upon contacting of the dosage form with a liquid medium.