(+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL)METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERSTHEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF

摘要

The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2- alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formu la (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of th e formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof a s an active substance.