发明名称 |
COMPOUND BINDING TO LEUKOCYTES AND MEDICINAL COMPOSITION CONTAINING THE COMPOUND IN LABELED STATE AS THE ACTIVE INGREDIENT |
摘要 |
<p>A compound binding to leukocytes, which comprises Met or Nle-Leu-Phe serving as the leukocyte-binding site of a formyl peptide receptor (FPR), a binding part comprising Ser or Thr elevating the binding ratios to monocytes and lymphocytes in all leukocytes, a group which can be labeled with a radioactive metal or a paramagnetic metal, and a spacer binding them shows binding properties specific to all leukocytes, i.e., neutrophilic leukocytes, monocytes and lymphocytes both in vivo and in vitro and can be labeled with a radioactive metal or a paramagnetic metal. Owing to these characteristics, this compound is highly useful in SPECT image diagnosis, PET image diagnosis, MRI image diagnosis and so on wherein imaging is performed in a site with vigorous leukocyte infiltration accompanied by an immune reaction in an individual.</p> |
申请公布号 |
WO2004029080(A1) |
申请公布日期 |
2004.04.08 |
申请号 |
WO2003JP12362 |
申请日期 |
2003.09.26 |
申请人 |
NIHON MEDI-PHYSICS CO., LTD.;SEKI, IKUYA;KAWAGUCHI, TAKAYOSHI;SHIRAKAMI, YOSHIFUMI |
发明人 |
SEKI, IKUYA;KAWAGUCHI, TAKAYOSHI;SHIRAKAMI, YOSHIFUMI |
分类号 |
A61K38/00;A61K38/08;A61K49/14;A61K51/08;A61P37/00;C07K7/02;C07K7/06;(IPC1-7):C07K7/02;A61K49/00;A61K51/00;A61N5/10 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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