MEDICINAL COMPOSITION FOR INHIBITING INCREASE IN BLOOD GASTRIN CONCENTRATION

摘要

A pyrrolopyridazine compound having a structure represented by the general formula (I) (wherein R<1> represents alkenyl, halogenoalkenyl, alkynyl, cycloalkyl, or optionally substituted cycloalkylalkyl; R<2> represents hydrogen or alkyl; R<3> represents hydrogen, alkyl, or hydroxyalkyl; R<4> represents hydrogen or alkyl; R<5> represents optionally substituted phenyl; A represents alkylene; and X represents oxygen or sulfur), a pharmacologically acceptable salt of the compound, or a pharmacologically acceptable ester of the compound. They are useful as a medicine for inhibiting the increase of blood gastrin concentration. Also provided is a medicinal composition comprising any of the pyrrolopyridazine compound, pharmacologically acceptable salt, and pharmacologically acceptable ester and a gastric hydrochloric acid secretoinhibitor having a benzimidazole skeleton. The composition is useful as a medicine for treatments for or prevention of ulcerative diseases which is reduced in side effects.