发明名称 |
FUNCTIONAL MUTATIONS IN RESPIRATORY SYNCYTIAL VIRUS |
摘要 |
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided. |
申请公布号 |
WO2004028478(A2) |
申请公布日期 |
2004.04.08 |
申请号 |
WO2003US30734 |
申请日期 |
2003.09.26 |
申请人 |
MEDIMMUNE VACCINES, INC.;JIN, HONG;LU, BIN;CHENG, XING;ZHOU, HELEN |
发明人 |
JIN, HONG;LU, BIN;CHENG, XING;ZHOU, HELEN |
分类号 |
A61K;A61K6/00;A61K35/76;A61K39/155;A61P31/14;C07K14/135;C12N7/01;C12N7/04;C12N15/00;C12N15/45;C12N15/86;C12Q1/68;C12Q1/70;G01N33/569 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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