IMMUNIZING COMPOSITION AND METHOD FOR INDUCING AN IMMUNE RESPONSE AGAINST THE SS-SECRETASE CLEAVAGE SITE OF AMYLOID PRECURSOR PROTEIN

摘要

The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an AssPP epitope spanning the ss-secretase cleavage site of AssPP and a method for inducing an immune response against the ss-secretase cleavage site of AssPP using this immunizing composition. The present invention is also directed to antibodies against the ss-secretase cleavage site of AssPP and their use in a method for inhibiting the formation of amyloid ss.