Surface antigens and proteins useful in compositions for the diagnosis and prevention of Lyme disease

摘要

A novel isolated surface antigen, which is expressed in vitro by spirochetes of Borrelia garinii strain IP90, is characterized by a relative molecular mass of 39.5 kDa and the ability to induce antibodies which kill spirochetes of the B. burgdorferi sensu lato strain IP90 by ADCK in vitro. Novel B. garinii cassette string protein or fragments thereof are also useful, as is the P39.5 protein in diagnosing Lyme disease and in compositions for treatment or prophylaxis thereof.