发明名称 |
PROCESS FOR THE PRODUCTION OF 6,7-DIHYDROXY STEROID COMPOUNDS BY ALLYLIC OXIDATION OF STEROID-5-ENE COMPOUNDS TO STEROID-5-ENE-7-ONE COMPOUNDS FOLLOWED BY HYDROBORATION AND OXIDATION AND INTERMEDIATES OF THIS PROCESS |
摘要 |
<p>Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding alpha,beta-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the alpha,beta-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.</p> |
申请公布号 |
EP1404700(A2) |
申请公布日期 |
2004.04.07 |
申请号 |
EP20020727121 |
申请日期 |
2002.05.22 |
申请人 |
INFLAZYME PHARMACEUTICALS, LTD. |
发明人 |
BURGOYNE, DAVID, L.;SHEN, YAPING;JI, GUEIJUN;ZHOU, YUANLIN;RAMACHANDRAN, KISHORE;PASCHALIDES, NICHOLAS, D.;KELLEHER, EUGENE W. |
分类号 |
A61K31/56;C07B53/00;C07J1/00;C07J11/00;C07J21/00;C07J31/00;C07J41/00;C07J53/00;(IPC1-7):C07J21/00 |
主分类号 |
A61K31/56 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|