| 摘要 |
A method for making a composition of magnetic nanoparticles, includes the step of forming magnetic nanoparticles, each within a protein template, wherein a liquid composition of said protein template or subunits thereof is subjected to a microporous membrane filtration step prior to the formation of the magnetic nanoparticles. The protein template may comprise flagellar L-P rings, microtubules, bacteriophages, chaperonins, virus capsids or preferably members of the ferritin family, most preferably apoferritin. The magnetic nanoparticles preferably comprise ferri- or ferro-magnetic materials, metal alloys, M-type or spinel ferrite. Also claimed is a method of treating a liquid composition of magnetic nanoparticles, each formed within a macromolecular template, the method including subjecting the composition to a microporous membrane filtration step. Further claimed is a composition of encapsulated magnetic nanoparticles, wherein at least 70% by weight of the nanoparticles are not in agglomerated form and wherein the composition comprises no more than 30% free encapsulating material, based on the total weight of encapsulating material in the composition. |
