发明名称 |
USE OF SODIUM CHANNEL BLOCKING COMPOUNDS AND ASPIRIN IN MANUFACTURING DRUGS FOR PRODUCING SYNERGISTIC ANALGESIC EFFECT IN MAMMALS |
摘要 |
<p>The use of a sodium channel blocker which binds to an alpha -subunit of the SS1 or SS2 site and aspirin as an analgesic is claimed. ACTIVITY : Analgesic. In the acetic acid writhing test, administration of tetrodotoxin at 0.79 Microg/kg, aspirin at 25.0 mg/kg or tetrodotoxin at 0.79 Microg/kg and aspirin at 25.0 mg/kg reduced writhing by 40.6%, 35.6% and 81.6% respectively. MECHANISM OF ACTION : Sodium-Antagonist.</p> |
申请公布号 |
EP1405639(A1) |
申请公布日期 |
2004.04.07 |
申请号 |
EP20020754135 |
申请日期 |
2002.06.18 |
申请人 |
WEX MEDICAL INSTRUMENTATION CO. LTD. |
发明人 |
KU, BAOSHAN;SHUM, HAY KONG |
分类号 |
A61K31/519;A61K45/00;A61K31/517;A61K31/52;A61K31/529;A61K31/616;A61P25/04;A61P29/00;A61P43/00;(IPC1-7):A61K31/517 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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