发明名称 |
Mobility-Modifying Cyanine Dyes |
摘要 |
The present invention provides a novel class of fluorescent cyanine dye compounds that are modified at one of the hetercyclic ring nitrogen atoms with a mobility-modifying moiety that permits the electrophoretic mobilities of polynucleotides labeled with the mobility-modifying cyanine dyes to be adjusted or tuned in a predictable fashion while retaining enzymatic activity. The ability to predictably tune the relative electrophoretic mobilities of the dyes permits the creation of sets of mobility-matched fluorescent dyes of a variety of structures for a variety of applications, including fluorescence-based 4-color nucleic acid sequencing reactions. |
申请公布号 |
US6716994(B1) |
申请公布日期 |
2004.04.06 |
申请号 |
US20000477270 |
申请日期 |
2000.01.04 |
申请人 |
APPLERA CORPORATION |
发明人 |
MENCHEN STEVEN M.;BENSON SCOTT C.;ROSENBLUM BARNETT B.;KHAN SHAHEER H. |
分类号 |
C09B23/00;C07F9/24;C07H21/00;C09B11/28;C09B23/02;G01N27/447;(IPC1-7):C07D209/02 |
主分类号 |
C09B23/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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