| 摘要 |
A compound of formula I:whereinA is a connecting chain of (C1-3) alkyl; B is O or S; R<1 >is H, (C1-6) alkyl, halo, CF3, or OR<1a >wherein R<1a >is H or (C1-6)alkyl; R<2 >is H or Me; R<3 >is H or Me; R<4 >is H, (C1-4) alkyl, (C3-4) cycloalkyl and (C1-4)alkyl(C3-7)cycloalkyl;W is selected fromwherein,a) one of Y is SO2 and the other Y is NR<5>, provided that both are not the same, wherein R<5 >is H, (C1-6)alkyl,(C3-6) cycloalkyl, the alkyl being substituted, COR<5o>, COOR<5p >or CONR<5p>PR<5q>; and each R<8 >is H, (C1-4) alkyl, (C3-6) cycloalkyl, or (C1-4) alkyl-(C3-6) cycloalkyl; or b) E is CR<8a>R<8b >wherein R<8a >and R<8b >is H, or alkyl and J is CH2; or J is CR<8a>R<8b >and E is CH2, and the dotted line represents a single bond; or c) E is C(O) and J is CR<8a>R<8b >or J is C(O) and E is CR<8a>R<8b >and the dotted line represents a single bond; or d) E and J are CR<8a>R<8b >and the dotted line represents a double bond. Compounds of formula I have activity against HIV WT and double mutant strains.
|
