发明名称 |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
摘要 |
Cytotoxic agents bearing a polyethylene glycol (PEG) linking group having a terminal active ester, cytotoxic conjugates comprising one or more cytotoxic agents linked to a cell-binding agent via PEG linking groups, and methods for producing both are disclosed. A therapeutic composition comprising a therapeutically-effective amount of one of the cytotoxic conjugates of the present invention, and a method of killing selected cell populations comprising contacting target cells, or tissue containing target cells, with an effective amount of one of the cytotoxic conjugates, are also disclosed.
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申请公布号 |
US6716821(B2) |
申请公布日期 |
2004.04.06 |
申请号 |
US20010024290 |
申请日期 |
2001.12.21 |
申请人 |
IMMUNOGEN INC. |
发明人 |
ZHAO ROBERT YONGXIN;MILLER MICHAEL LOUIS;WIDDISON WAYNE CHARLES;CHARI RAVI V. J. |
分类号 |
A61K31/337;A61K31/537;A61K39/395;A61K47/48;A61P35/00;(IPC1-7):A61K31/70;A61K31/535;C07H15/24;C07D491/00;C07D305/00 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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