摘要 |
Naphthalene derivatives represented by formula [I]: <IMG> (wherein A is a hydrogen atom, a hydroxy group, a C1-C11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C1-C12 aliphatic or alicyclic, saturated or unsaturated hydrocarbon group where the alkyl may be substituted with a C6-C10 allyloxy group; B represents O, S, CH2, O-C2, S-CH 2, CO, or CHOR1 C represents CO, CR2R1CO, CH2CH2CO, or CH=CHCO; D represents a hydrogen atom, NO2, NH2, CO2R4, or a group having the following . formula [II]: <IMG> (wherein G represents a hydrogen atom, OH, SO2NH2, CO2R6, CN, or a tetrazol-5-yl group); E represents a hydrogen atom, OH, SO2NH, CO2R5, CN, or a tetrazol-5-yl group; F represents a hydrogen atom, a C1-C4 lower alkyl group, a nitro group , or a halogen atom; and R1, R3, R3, R4, R'5 and R6 are , independently each other, a hydrogen atom or a C1-C4 lower alkyl group); pharmacologically acceptable salts thereof, or pharmacologically acceptable solvates thereof, which have, for example, an inhibitory effect o n the production of IgE antibodies, and will be useful for prophylaxis and/or treatment of allergic diseases.
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