发明名称 |
IMMUNOLOGICALLY SIGNIFICANT HERPES SIMPLEX VIRUS ANTIGENS |
摘要 |
<p>The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.</p> |
申请公布号 |
PL355265(A1) |
申请公布日期 |
2004.04.05 |
申请号 |
PL20000355265 |
申请日期 |
2000.09.28 |
申请人 |
UNIVERSITY OF WASHINGTON;CORIXA CORP.;FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
KOELLE DAVID M.;CHEN HONGBO;COREY LAWRENCE;HOSKEN NANCY ANN;MCGOWAN PATRICK;FLING STEVEN P.;POSAVAD CHRISTINE M. |
分类号 |
G01N33/50;A61K35/12;A61K39/00;A61K39/245;A61K39/25;A61K39/39;A61P31/22;C07K14/035;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N7/00;C12N15/09;C12N15/38;C12P21/02;G01N33/15;G01N33/569 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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