ORALLY ADMINISTRABLE ACID STABLE ANTI ULCER BENZIMIDAZOLE DERIVATIVES.

摘要

Orally administrable acid stable anti ulcer benzimidazole derivatives which are polymer based. The process of preparation comprises condensing a benzimidazole with a biocompatible partially orally biodegradable synthetic cross linked polymer in aqueous medium at 5 80 C and pH 4 11 under inert atmosphere. The weight percentage of benzimidazole with respect to the polymeric benzimidazole is 1 50. The reaction mixture is cooled and the product is isolated and dried at 25 45 C. There is also provided a formulation of the polymeric benzimidazoles in combination with pharmaceutically acceptable excipients.