| 摘要 |
PURPOSE: A monoclonal antibody specific to human mitochondrial adenylate kinase isozyme 3(AK3) is provided, thereby accurately detecting AK3 which is as a detecting marker of heart disease, so that heart disease can be accurately diagnosed. CONSTITUTION: A monoclonal antibody specific to human mitochondrial adenylate kinase isozyme 3(AK3) comprises 4 or more of CDRs(complementarity determining regions) selected from the group consisting of (a) SEQ ID NO: 41 to SEQ ID NO: 46, (b) SEQ ID NO: 47 to SEQ ID NO: 52, (c) SEQ ID NO: 53 to SEQ ID NO: 58, (d) SEQ ID NO: 59 to SEQ ID NO: 64, (e) SEQ ID NO: 65 to SEQ ID NO: 70, (f) SEQ ID NO: 71 to SEQ ID NO: 76, (g) SEQ ID NO: 77 to SEQ ID NO: 82, (h) SEQ ID NO: 83 to SEQ ID NO: 88, (i) SEQ ID NO: 89 to SEQ ID NO: 94 and (j) SEQ ID NO: 95 to SEQ ID NO: 100, wherein the monoclonal antibody is produced from hybridoma selected from KCLRF-BP-00058 to KCLRF-BP-00066.
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