VARIANT POLYNUCLEOTIDE AND NUCLEIC ACID MOLECULE USABLE FOR GENE DIAGNOSIS OF SENSITIVITY TO MEDICAMENT BY USING INHIBITION OF THYMIDYLIC ACID SYNTHETIC ENZYME AS MECHANISM OF ACTION

摘要

PROBLEM TO BE SOLVED: To provide a nucleic acid probe and a primer usable for judgment of sensitivity to a medicament by using the inhibition of a thymidylic acid synthetic enzyme as a mechanism of action.

SOLUTION: The nucleic acid molecule can detect the mutation in which a codon encoding an arginine residue at the 115th position of the thymidylic acid synthetic enzyme is converted to a nonsense codon in a gene of the thymidylic acid synthetic enzyme. The nucleic acid molecule contains a polynucleotide having the mutation in which the codon encoding the arginine residue at the 115th position is converted to the nonsense codon in the polynucleotide encoding the protein containing a specific amino acid sequence, or a nucleotide fragment hybridizing with the polynucleotide complementary to the polynucleotide.

COPYRIGHT: (C)2004,JPO