发明名称 |
AN INHIBITOR OF THE SHH SIGNALLING PATWAY AND A TESTOSTERONE SUPRESSING AGENT FOR THE TREATMENT OF CANCER |
摘要 |
<p>A method of protecting a patient from possible adverse effects of a treatment involving inhibition of the SHH-signalling pathway in the patient, the method comprising suppressing testosterone or its effect in the patient. A method of treating a proliferative disease such as cancer in a patient the method comprising inhibiting the SHH-signalling pathway and suppressing testosterone or its effect in the patient. Typically, the SHH-signalling pathway is inhibited using cyclopamine or a derivative thereof, and testosterone is suppressed using any one or more of a GnRH antagonist, a GnRH agonist, an androgen antagonist or a 5a-reductase inhibitor.</p> |
申请公布号 |
WO2004026304(A1) |
申请公布日期 |
2004.04.01 |
申请号 |
WO2003GB04117 |
申请日期 |
2003.09.17 |
申请人 |
MEDICAL RESEARCH COUNCIL;THOMSON, AXEL, ANDREAS |
发明人 |
THOMSON, AXEL, ANDREAS |
分类号 |
A61K31/435;A61K31/4741;A61K31/4985;A61K31/517;A61K45/06;A61P35/00;(IPC1-7):A61K31/435;A61K31/498 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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