| 摘要 |
PURPOSE: A process for producing aromatic cyclic derivatives using palladium-loaded zeolite is provided, thereby simplifying the production process of aromatic cyclic derivatives and reducing the production costs by reuse of palladium as catalyst. CONSTITUTION: A process for producing aromatic cyclic derivatives of the formula(1) using palladium-loaded zeolite comprises reacting a compound of the formula(2) or N-acetylated derivatives thereof with a compound of the formula(3) in the presence of chlorine-containing salt and base using palladium-loaded zeolite as catalyst, wherein X is carbohydrate radical and forms aromatic ring with carbon; the aromatic ring comprises one or more hetero selected from N, S and O and is substituted by C1-C4 alkyl, C1-C4 alkoxy or pyrolidinyl; R1 and R2 are independently hydrogen, C1-C18 alkyl, C1-C18 alkoxy - C1-C18 alkyl, C3-C18 cycloalkenyl, phenyl, C1-C4 alkyl and/or halogen substituted phenyl, benzyl, (tetrahydro-pyran-2-yl) oxy-C1-C18 alkyl, (4-methylphenyl)sulfonyl, thiophenyl optionally substituted with acetyl, quinolinyl, pyridinyl optionally substituted with C1-C18 alkyl, tri-C1-C18 alkyl-silyl, or 4,5-dihydro-thiopenyl optionally substituted with acetyl; and Y is halogen.
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