发明名称 |
Non-adenoviral gene product-based complementing cells for adenoviral vectors |
摘要 |
The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene product that complements in trans for a deficiency in at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.
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申请公布号 |
US2004063203(A1) |
申请公布日期 |
2004.04.01 |
申请号 |
US20030695605 |
申请日期 |
2003.10.28 |
申请人 |
GENVEC, INC. |
发明人 |
BROUGH DOUGLAS E.;GALL JASON G. D.;KOVESDI IMRE |
分类号 |
C12N5/08;C12N5/10;C12N7/00;C12N7/01;C12N7/02;(IPC1-7):C12N5/08;C12N15/861 |
主分类号 |
C12N5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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