发明名称 |
NOVEL URACIL DERIVATIVES AND MEDICINAL USE THEREOF |
摘要 |
<p>It is intended to provide an uracil derivative represented by the following general formula (I): (I) wherein X represents a group selected from among NHCO, NHCH2, CO, CONH and CH2NH; R<1> represents hydrogen or optionally substituted C1-6 alkyl; R<2> represents a group of the following general formula (II) or (III): (II) (III) (wherein m is 0 or 1; n is an integer of from 1 to 3; Y represents OH or NH2; and a dotted line shows a binding position), provided that when R<2> is a group of the general formula (III), X represents NHCO or NHCH2; R<3> and R<4> independently represent each hydrogen or C1-6 alkyl; and Ar represents phenyl substituted by C1-6 alkyl at the o- and m-positions, optionally substituted heteroaryl or a bicyclic aromatic group; its pharmaceutically acceptable salt, and a remedy containing the above uracil derivative or its pharmaceutically acceptable salt as the active ingredient for, in particular, allergic diseases relating to a type IV allergic reaction, i.e., a novel compound useful in treating diseases in which a type IV allergic reaction participates and a remedy for allergic diseases containing the same as the active ingredient.</p> |
申请公布号 |
WO2004026842(A1) |
申请公布日期 |
2004.04.01 |
申请号 |
WO2003JP11859 |
申请日期 |
2003.09.17 |
申请人 |
SUMITOMO PHARMACEUTICALS CO., LTD.;ISOBE, YOSHIAKI;TOBE, MASANORI;INOUE, YOSHIFUMI;ISOBE, MASAKAZU |
发明人 |
ISOBE, YOSHIAKI;TOBE, MASANORI;ISOBE, MASAKAZU |
分类号 |
A61K31/513;A61P17/04;A61P37/08;C07D239/54;C07D239/545;C07D405/06;C07D405/12;C07D405/14;(IPC1-7):C07D239/54 |
主分类号 |
A61K31/513 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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