发明名称 |
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS |
摘要 |
<p>Compounds represented by formula (1), wherein R<1> is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R<2> is H or methyl; R<3> is H or (C1-4)alkyl; R<4> is H or (C1-4)alkyl; R<5> is (C1-4)alkyl, (C1-4)alkyl(C3-7)cyclo-alkyl or (C3-7)cycloalkyl; and W is a fused phenyl-5 or 6-membered heterocycle having one or two heteroatoms selected from N or S; or W is phenyl, 1,1'-biphenyl, 2, 3-dihydro-1H-indene, 1, 2, 3, 4-tetrahydronaphthyl, or naphthyl; said W being optionally substituted with (C1-4)alkyl, which in turn can be optionally substituted with a carboxy or (C1-4)alkoxycarbonyl, or a salt or ester thereof. The compounds have inhibitory activity against Wild Type, single and double mutant strains of HIV.</p> |
申请公布号 |
WO2004026875(A1) |
申请公布日期 |
2004.04.01 |
申请号 |
WO2003CA01410 |
申请日期 |
2003.09.15 |
申请人 |
BOEHRINGER INGELHEIM (CANADA) LTD.;YOAKIM, CHRISTIANE;O'MEARA, JEFFREY;SIMONEAU, BRUNO;OGILVIE, WILLIAM, W.;DEZIEL, ROBERT |
发明人 |
YOAKIM, CHRISTIANE;O'MEARA, JEFFREY;SIMONEAU, BRUNO;OGILVIE, WILLIAM, W.;DEZIEL, ROBERT |
分类号 |
A61P31/18;C07D471/22;(IPC1-7):C07D471/22;A61K31/551 |
主分类号 |
A61P31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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