| 摘要 |
The present invention provides methods for the treatment and prevention of intermittent claudication or Alzheimer's disease in a subject, comprising administering to a subject a formulation comprising a precursor of NO, e.g., L-arginine and a formulation comprising an agonist of eNOS, e.g., and HMG-CoA reductase inhibitor, or a formulation comprising both L-arginine and an HMG-CoA reductase inhibitor. The invention further provides that the formulations used to treat or prevent intermittent claudication or Alzheimer's disease contain at least one controlled release agent. In a further embodiment, the production of NO is substantially uniform over a prolonged period of time. |
