摘要 |
A treatment solution used to prevent posterior capsular opacification is appied or introduced into the lens capsular bag before, during, or after cataract surgery. The treatment solution comprises an ion transport mechanis m interference agent, which either alone or in combination with other treatmen t agents such as an osmotic stress agent and an agent to establish a suitable pH, selectively induces detachment and/or death of lens epithelial cells suc h that posterior capsular opacification is prevented. While the ion tranposrt mechanism interference agent is capable of interfering with the cellular mechanisms and cell ion distribution of a broad range of cells, a concentration of agent is selected such that the treatment solution interfer es selectively with the cellular mechanisms of lens epithelial cells while leaving other ocular cells substantially unharmed. The treatment solution selectively induces cellular death and/or detachment of lens epithelial cell s while other ocular cells and tissue remain substantially unharmed and withou t lengthly preoperative pre-treatment.
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