发明名称 |
METHOD OF PREPARING AMINO ACID TAXANE DERIVATIVES AND POLYMER CONJUGATES CONTAINING THE SAME |
摘要 |
Methods of preparing amino acid-substituted taxanes such as: (4 of Fig. 1) using selected blocked amino acids are disclosed. After coupling of the blocked amino acid to the taxane, deprotection is carried out with about an equimolar amount of a secondary amine thus substantially avoiding base-catalyzed hydrolysis of amino acid from the taxane. The preferred amino acid-taxanes are useful as intermediates in the production of polymer conjugated therapeutic compositions or as part of pharmaceutically acceptable formulations. |
申请公布号 |
WO2004026230(A2) |
申请公布日期 |
2004.04.01 |
申请号 |
WO2003US27941 |
申请日期 |
2003.09.05 |
申请人 |
ENZON, INC. |
发明人 |
ZHAO, HONG;GREENWALD, RICHARD, B. |
分类号 |
C07D305/14;C07D409/12 |
主分类号 |
C07D305/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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