发明名称 |
Modified granulocyte colony stimulating factor (g-csf) with reduced immunogenicity |
摘要 |
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of granulocyte colony stimulating factor (G-CSF) to result in granulocyte colony stimulating factor (G-CSF) proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.
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申请公布号 |
US2004062749(A1) |
申请公布日期 |
2004.04.01 |
申请号 |
US20030467396 |
申请日期 |
2003.08.05 |
申请人 |
CARR FRANCIS J.;CARTER GRAHAM;JONES TIM;WILLIAMS STEPHEN |
发明人 |
CARR FRANCIS J.;CARTER GRAHAM;JONES TIM;WILLIAMS STEPHEN |
分类号 |
C12N15/09;A61K9/70;A61K38/00;A61K38/11;A61K38/18;A61K47/02;A61K47/12;A61K48/00;A61P37/02;C07K7/06;C07K7/08;C07K14/535;C07K14/54;C07K16/18;C07K16/28;C07K16/30;C07K16/46;C12N15/27;C12P21/02;G06F19/16;G06F19/18;(IPC1-7):C07K14/535;A61K38/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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