WT1 SUBSTITUTION PEPTIDES

摘要

It is intended to provide novel WT1 substitution peptides in which a cysteine residue is substituted by a specific amino acid residue, polynucleotides encoding these peptides, cancer vaccines with the use of the above peptides or polynucleotides either in vivo or in vitro, etc. Namely, a peptide containing the amino acid sequence represented by the following general formula and having a CTL-inducing activity: X-Y-Thr-Trp-Asn-Gln-Met-Asn-Leu (SEQ ID NO:4) wherein X represents Ser, Ala, Abu, Arg, Lys, Orn, Cit, Leu, Phe or Asn; and Y represents Tyr or Met; a polynucleotide encoding this polypeptide; and a cancer vaccine, etc. containing the peptide or polynucleotide as the active ingredient.