PROCESS FOR DECREASING AGGREGATE LEVELS OF PEGYLATED PROTEIN
摘要
The present invention is directed generally to recombinant methods for makin g a desired pegylated protein and pooling of same. These method(s) yield a polypeptide product containing reduced levels of aggregate thereof pooled to provide the desired pegylated isoforms thereof.
申请公布号
CA2498886(A1)
申请公布日期
2004.04.01
申请号
CA20032498886
申请日期
2003.09.22
申请人
PHARMACIA CORPORATION
发明人
BUCKLEY, JOHN J.;BOYLE, DENIS M.;RATHORE, ANURAG S.;JOHNSON, GARY V.;AYKENT, SERDAR;TOAL, MICHELE;STEINMEYER, DAVID E.
