发明名称 NOVEL DIFLUORINATED GEM COMPOUNDS, PREPARATION METHODS THEREOF AND APPLICATIONS OF SAME
摘要 The invention relates to a difluorinated gem compound having formula (I) wherein R<1> is a group comprising an alkyl chain that is substituted by at least one amine, amide or acid function, R<2> is a hydrogen atom H or a free or protected alcohol function, R<3> is group H, CH3, CH2OH, CH2-OGP wherein GP is a protecting group such as an alkyl, benzyl (Bn), trimethylsilyl (TMS), tert-butyldimethylsilyl (TBDMS), tert-butyldiphenylsilyl (TBDPS), acetate (Ac) group, etc. and Y, Y', Y" are independent groups wherein Y, Y', Y" = H, OR, N3, NR'R , SR' , etc. with R = H, Bn, Ac, TMS, TBDMS, TBDPS, etc., R', R" = H, alkyl, allyl, Bn, tosylate (Ts), C(=O)-alkyl, C(=O)-Bn, etc., R' = H, alkyl, Ac. The invention applies in particular to the use of said compound for the preparation of antitumoral, antiviral, hypoglycaemic and anti-inflammatory medicaments and compounds for immunology and cosmetology or glycopeptide analogues of antifreeze molecules.
申请公布号 WO2004014928(A3) 申请公布日期 2004.04.01
申请号 WO2003FR02330 申请日期 2003.07.23
申请人 INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN(INSA);QUIRION, JEAN-CHARLES;PANNECOUCKE, XAVIER;D'HOOGE FRANCOIS;MARCOTTE, STEPHANE;CASTELOT - DELIENCOURT - GODEFROY, GERALDINE;JUBAULT, PHILIPPE;GOUGE, VANESSA 发明人 QUIRION, JEAN-CHARLES;PANNECOUCKE, XAVIER;D'HOOGE FRANCOIS;MARCOTTE, STEPHANE;CASTELOT - DELIENCOURT - GODEFROY, GERALDINE;JUBAULT, PHILIPPE;GOUGE, VANESSA
分类号 A61P3/08;A61P31/12;A61P35/00;C07F7/18;C07H15/18 主分类号 A61P3/08
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