NOVEL BENZOTHIENYL OR INDOLE DERIVATIVES, AND USE THEREOF AS INHIBITORS OF PRENYL TRANSFERASE PROTEINS

摘要

The invention concerns compounds of general formula (I), wherein, in particular: W represents H, SO>2<R>5<, CO(CH>2<)>n<R>5<, (CH>2<)>n<R>6<, CS(CH>2<)>n<R>5<; X represents S or NH; Y represents (CH>2<)>p<, CO, (CH>2<)>p<CO, CH=CH-CO; Z represents a heterocycle, imidazole, benzimidazole, isoxazole, tetrazole, oxadiazole, thiadazole, pyridine, quinazoline, quinoxaline, quinoline, thiophene; R>1< REPRESENTS COOR>6<, CONR>6<R>7<, CO-NH-CH(R>6<)-COOR>7<, CH>2<NR>6<R>7<, CH>2<OR>6<, (CH>2<)>p<R>6<, CH=CHR>6<; R>2< represents in particular hydrogen, C>1<-C>10< alkyl, a substituted or unsubstituted phenyl; R>3< AND R>4< REPRESENT HYDROGEN, C>1<-C>6< ALKYL; R>5< represents a substituted or unsubstituted phenyl or naphthyl; R>6< AND R>7<, identical or different, represent hydrogen, C>1<-C>15< alkyl, a heterocycle, an aryl; n represents 0 to 10; p represents 1 to 6.