| 摘要 |
<p>A polypeptide containing an amino acid sequence identical or substantially similar to a 24 residue amino acid sequence, given in the specification, its amide, ester or their salt, is new. Independent claims are also included for: (1) a partial peptide of the novel polypeptide, its amide, ester or their salt; (2) a polynucleotide encoding the novel polypeptide or its partial peptide; (3) a recombinant vector containing the polynucleotides of (2); (4) a transformant which is transformed with the recombinant vector of (3); (5) producing the novel polypeptide, its partial peptide or their amide, ester or salt by culturing the transformant; (6) an antibody against the novel polypeptide, its partial peptide or their amide, ester or salt; (7) a polynucleotide containing a base sequence or a part of it complementary to the polynucleotide of (2); (8) a method for screening compounds or their salts promoting or inhibiting activity of the novel polypeptide, its partial peptide or their amide, ester or salt by using them; (9) a kit for screening compounds or their salts promoting or inhibiting activity of the polypeptide, its partial peptide or their amide, ester or salt by containing them; (10) promoters or inhibitors screened by the method of (9); (11) diagnostics containing the polynucleotide of (2) or antibodies of (6); (12) preventing or treating neurodegenerative diseases or brain dysfunction by administering an effective dose of the novel polypeptide, its partial peptide or their amide, ester or salt, the polynucleotide of (2), or the screened compounds or their salts to mammals; and (13) the use of the novel polypeptide, its partial peptide or their amide, ester or salt, the polynucleotide of (2), or the screened compounds or their salts for producing remedies or preventives in treating neurodegenerative diseases or brain dysfunction. ACTIVITY : Neuroprotective; Cerebroprotective; Cytostatic; Immunomodulator; Antiinfective; Cardiant. No biological data is given. MECHANISM OF ACTION : Gene therapy.</p> |
