Protein complexes of the Tumor necrosis factor-alpha (TNF-alpha) signalling pathway

摘要

A protein complex comprising at least one first and second protein of the Tumor Necrosis Factor-alpha(TNF-alpha)-signaling pathway, is new. Independent claims are included for the following: (1) a process for preparing the complex; (2) a component of the complex; (3) a protein selected from any of the proteins listed in the specification; (4) a nucleic acid encoding the protein; (5) a construct, preferably a vector construct, comprising the nucleic acid and at least one further nucleic acid, which is normally not associated with nucleic acid, or at least two separate nucleic acid sequences each encoding a different protein, or its functionally active fragment, derivative, homologue, or variant; (6) a host cell, containing the vector comprising at least one nucleic acid and/or the construct, or containing several vectors each comprising at least one nucleic acid encoding at least one protein; (7) an antibody or its fragment containing its binding, which binds the complex and which does not bind any of the proteins of the complex when uncomplexed and an antibody or its fragment antibody containing the binding domain, which binds to any of the proteins; (8) a kit comprising in one or more containers: the complex, nucleic acid, or cells; and optionally, further components such as reagents, buffers and working instructions; (9) an array, preferably a microarray, in which at least a complex, protein or antibody is attached to a solid carrier; (10) a process for modifying a substrate of the complex; (11) a pharmaceutical composition comprising the protein complex and/or protein; (12) a method for screening for a molecule that binds to the complex and/or the protein; (13) a method for screening for a molecule that modulates directly or indirectly the function, activity, composition or formation of the complex; (14) a method for producing a pharmaceutical composition; (15) use of an siRNA-Oligonucleotide in the preparation of a medicament for the modulation of expression of a series of proteins as listed in the specification; (16) a method for diagnosing or screening for the presence of a disease or disorder or a predisposition for developing a disease or disorder in a subject, which disease or disorder is characterized by an aberrant amount of, component disposition of, or intracellular localization of the complex; and (17) a method for treating or preventing a disease or disorder characterized by an aberrant amount of, activity of, component composition of or intracellular localization of, the complex. ACTIVITY : Antiinflammatory; CNS-Gen; Antiarthritic; Antirheumatic; Cytostatic; Antibacterial. No biological data given. MECHANISM OF ACTION : Gene therapy.