COMPOUNDS USED TO TREAT ALCOHOLISM

摘要

N,N'-bis-(3-Aminopropyl)-cyclohexane-1,4-diamine (I) is new. N,N'-bis-(3-Aminopropyl)-cyclohexane-1,4-diamine of formula (I) and its physiologically hydrolyzable amides, salts and hydrates are new (including stereoisomers and stereoisomer mixtures). [Image] An independent claim is also included for the preparation of (I). ACTIVITY : Antialcoholic. In tests in genetically alcoholic mice, oral administration of the tetramethanesulfonate monohydrate of (I) at 20 mg/kg for 6 days reduced alcohol consumption by 25 %. MECHANISM OF ACTION : None given.