CANCEROUS METASTASIS INHIBITORS CONTAINING CARBACYCLIC PHOSPHATIDIC ACID DERIVATIVES

摘要

New carbacyclic phosphatidic acid derivative (I) comprises a cancer metastasis inhibitor : Cancer metastasis inhibitor comprises a carbacyclic phosphatidic acid derivative of formula (I). [Image] R : 1-30C alkyl, 2-30C alkenyl or 2-30C alkynyl all optionally containing a cycloalkyl or aromatic ring; M : H or cation. ACTIVITY : Cytostatic. Administration of cyclic phosphatidic acid-19 (cPA-19) at 0.008 mg by tail vein injection to mice with B16-F0 melanoma gave 0/6 mice with metastasis compared to 6/6 for a control. MECHANISM OF ACTION : None given.